Global Drug Design & Development Review

  • Address

    Office #1,2, First Floor, Fazal Arcade,
    F-11 Markaz, Islamabad, Pakistan.

  • Email address

    managingeditor@gdddrjournal.com
    Monday to Friday 9am - 7pm

  • Contact information

    info@gdddrjournal.com, +92 332 9147618
    Monday to Sunday 24 Hours
  • Publishing research Since2016
  • Publication FrequencyAnnual
  • Access TypeOpen Access

Global Drug Design and Development Review (GDDDR) intends to promote qualitative and quantitative researches and findings with the help of newly emerging tools and patterns utilized in experiments, observations, interviews, analysis and surveys by encircling all major segments of Drug design and Interdisciplinary academic and research disciplines. GDDDR is a Inter-disciplinary, quarterly published, double-blind peer-reviewed research journal which encompasses major disciplines of Drug design in general with specific interest in the sub-disciplines detailed below. In order to facilitate the translation of cutting-edge drug delivery technologies into improved patient outcomes, it is important to establish a platform for rigorous, peer-reviewed research that bridges the gap between drugs design, development, and clinical practice. All the review articles published will be comprehensively peer-reviewed by the team of GDDDR to ensure their scientific authenticity, innovation, and excellence.

 

  • GDDDR contains notable research contributions selected on the base of merit.
  • It serves as a national and international platform to undergrad students and researchers.
  • It focuses to target the researchers from different fields serving in the vicinity of drug design and development.
  • GDDDR functions as a multi-disciplinary research deploying various fields.
  • It encourages and supports the researchers and creates a network between the undergrad students, researcher scholars and teachers to carry out inventive research ideas in a productive way.



Global Prevalence and Mortality of Type-2 Diabetes from 1990 to 2019, with Future Projections to 2023 and 2050: a Systematic Review Hafiz Muhammad Usman Abid, Muhammad Hanif, Muhammad Naveed Bin Afzal, Muhammad Azeem, Dur e Shahwar, Khalid Mahmood Abstract:

Type-2 diabetes (T2DM) is a key public health issue due to its high prevalence and mortality rate. This review estimates future global trends in T2DM prevalence and mortality using the Forecast exponential smoothing (ETS) model. By 2050, estimated prevalence and mortality for all ages are 10.23% and 2.05 million, respectively, and for adults (>20 years) are 11.97... read more PDF     Full Text

Innovation of Custom-Made Silicone Insoles for Diabetic Patients Asra Maqbool, Saleh Shah, Saad Saleem, Laraib Abstract:

Diabetic foot ulcers, caused by diabetes-related nerve and blood vessel damage, can lead to amputations. Silicone insoles help prevent ulcers but are often expensive. Affordable, customized insoles are available, making prevention more accessible. This research aims to create affordable, locally manufactured silicone insoles for diabetic foot ulcers, reducing costs ... read more PDF     Full Text

Scope

The scope of this journal is extended to the researchers working as pharmacists, chemists, chemical engineers, biologists, oncologists working in R&D of drugs and biologics, scientists working in pharmacological engineering and biotechnology. It implements multi-disciplinary fields, GDDDR is publishing the review articles in the following domains;

  • Medicinal Chemistry
  • Structural or molecular biological studies elucidating molecular recognition processes.
  • Fragment-based drug discovery.
  • Drug target identification and validation.
  • Pharmaceutical Technology
  • Design, synthesis, and biological evaluation of novel biologically active compounds.
  • Phenotypic screening and target deconvolution.
  • Preclinical and Clinical Pharmacology
  • Preclinical development studies.
  • Translational animal models.
  • Mechanisms of action and signaling pathways.
  • Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development.
  • Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing).
  • Pharmacognosy
  • Isolation, structural characterization, biosynthesis, bioengineering and pharmacological evaluation of natural products.
  • Bioinformatics
  • In Silico drug designing.
  • Identifying targets for drug discovery using bioinformatics.
  • Computer-aided drug designing
  • Biotechnology
  • Use of fluorescent probe for fast and quantitative detection of chemicals in blood
  • genomics-based drug design and discovery
  • Clinical Practice
  • Pharmaceutical formulation science: is covered in detail,  with a focus on dosage form development and design,  stability investigations, and formulation techniques that  increase drug bioavailability and patient compliance.
  • Clinical Pharmacokinetics: This field of study focuses on  the pharmacokinetics of medications administered via  various delivery systems. It examines the factors that affect drug distribution, metabolism, and elimination, with particular attention to how these  aspects relate to clinical outcomes.
  • Cover a wide range of therapeutic areas, including  oncology, neurology, cardiology, and infectious illnesses, and explain how advances in drug delivery technologies  are increasing therapy options in each area.
  • Address the unique requirements of pediatric and elderly patients, with an emphasis on age-appropriate drug administration methods, dosages, and safety considerations.
  • Drug-Drug Interactions: Examine possible drug-drug interactions that might result from intricate drug delivery systems, providing guidance on how to manage polypharmacy and reduce unfavorable effects.
  • Publish studies on the biopharmaceutical elements of drugs delivery, including as drug solubility, permeability, and formulation techniques to address absorption issues.
  • Keep readers informed on cutting-edge drug delivery breakthroughs, including 3D printing, implantable technology, and gene delivery systems.
  • Articles on methods for educating patients and healthcare professionals about drug delivery systems should be included in the section on patient education and  counselling to help patients understand their medications and adhere to them.
  • Safety and toxicology: Discuss potential toxicity, side  effects, and ways to improve safety profiles as they relate  to drug delivery systems.
  • Reflect a worldwide perspective by including studies and  reviews from other countries, encouraging the sharing of  knowledge and best practices in clinical pharmacy practice.
  • Drug Design and Molecular Insights: Emphasise papers  that connect drug design principles with drug delivery  strategies, illuminating the molecular underpinnings of drug interactions and therapeutic mechanisms.

Editorial Board
Chief Editor

Dr. Fahad Pervaiz, Associate Professor in Pharmaceutics, Department of Pharmaceutics, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
fahad.pervaiz@iub.edu.pk

Editor

Dr. Muhammad Farhan Sohail, Associate Professor, Riphah International University, Raiwind Road Campus, Lahore, Punjab, Pakistan.
farhan.sohail@riphah.edu.pk

Associate Editor

Dr. Malik Ihsan Ullah Khan, Assistant Professor, Institute of Molecular Biology and Biotechnolog, University of Lahore, Punjab, Pakistan.
ihsan.ullah@imbb.uol.edu.pk

Managing Editor

Maria Hassan Kiani, Lecturer, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
marria.h.kyani@gmail.com

Advisory Board
Member

Dr. Waqar Aman, Associate Professor, School of Pharmacy, University of Management and Technology, Lahore, Punjab, Pakistan.
waqar.aman@umt.edu.pk

Member

Dr. Muhammad Shafeeq ur Rahman , Associate Professor, Faculty of Pharmaceutical Sciences, University of Central Punjab Lahore, Punjab, Pakistan.
shafeeq.rahman@ucp.edu.pk

Member

Dr. Muhammad Imran Khan, Professor, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Raiwind Road Campus, Lahore, Punjab, Pakistan.
Niazipharmacistms@yahoo.com

Member

Dr. Amina Riaz, Assistant Professor, Department of Pharmacy, The Women University Multan, Punjab, Pakistan.
aminaranjha@yahoo.com


Fragment-Based Approach towards the Design of Potent and Versatile Anti-Cancer Agents Sana Ali Zahra , Ayesha Imran , Faiza Khalid , Mubashir Rehman , Abstract:

Despite years of clinical research and trials of encouraging new therapies, cancer remains a leading cause of morbidity and mortality. The fragment-based drug discovery has evolved formerly as an efficient approach for identification, optimization, and generation of lead. After identifying the fragments having binding affinity with the target using computational method for fragment screening, t... read more PDF     Full Text     Views (5764)

A Review of Parenteral Administration of Testing Substance in Rabbit and Mice Muhammad Shehzeb Ashraf, Iqra Rehman, Gul Shahnaz, , Abstract:

There are many publications that deal with administration of test substances to animals and removal of blood samples for different objectives. Parenteral route of drug administration includes further different routes i.e., drug administration through muscles (IM route) through veins (IV route) and through subcutaneous route. We can manage to check the outcomes of test substances within minutes ... read more PDF     Full Text     Views (5433)

Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing Duaa Aslam Chaudhry , Urooj Fatima , Kainat Waqar , Mubashar Rehman , Abstract:

Pharmacokinetic modeling helps to estimate the ADME parameters of all the natural and synthetic drug substances in humans and animals. There are two types of approaches for predicting the kinetic processes inside the body i.e., model approach and model independent approach. Model approach is further divided into compartmental and physiological models and model independent approach consists of n... read more PDF     Full Text     Views (3342)

Evaluation Of The Anti-Inflammatory Pharmacological Effects Of Artemisia Annua Extracts Artemisinin In Vitro And In Vivo Muhammad Saqib, Samiyah Tasleem, Kamran Afzal, Faisal Rashid, Asma Siddiq, Ali Asghar Bhutto Abstract:

Artemisia annua L. is acknowledged as a traditional medicinal plant bearing potent antimalarial, read more PDF     Full Text     Views (2717)

A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs. Rabia Mazhar, Fariah Qaiser, Sana Ali Zahra, Syeda Komal Fatima, Imran Khan Abstract:

Oral route of drug administration is the most common among all routes and hence their pharmacokinetic and pharmacodynamic factors are substantial to study. Among such factors, GIT absorption is the key factor in new drug development affecting the efficacy as well as safety of the drug. Different protocols have now been developed for the usage of in vitro also the in vivo as well as in situ meth... read more PDF     Full Text     Views (2577)

A Comprehensive Insight on Pharmacokinetics Urooj Naseem, Fatima Iqbal, Gul Shahnaz, , Abstract:

Pharmacokinetics can be defined as what the body does to a drug. The basic parameters of pharmacokinetics are discussed here including absorption, distribution, metabolism, and excretion. Characteristics and pathways taken by these drugs are determined by these parameters. The mechanism followed by these parameters are also discussed. Furthermore, the factors affecting these parameters includin... read more PDF     Full Text     Views (2452)

Quality Analysis of Refrigerated Strawberry Juice with TSS of 20.5 Treated with Sodium Benzoate and Potassium Sorbate and Citric Acid Shakoor Wisal, Ikram Ullah, Saifullah , Alia Gul Abstract:

The aim of this research was carried out to investigate the effect of different sugar concentrations and chemical preservatives and storage temperature, i. e. refrigeration temperature (4-10oC) on the physicochemical and sensory attributes of strawberry juice stored for one year. The samples were numbered as, TR28=Strawberry juice (20.5 brix) with 0.1 Percent sodium benzoate, TR30=Strawberry ju... read more PDF     Full Text     Views (2384)

A Review of Novel Techniques for Nanoparticles Preparation Irsah Maqbool , Sobia Noreen , , , Abstract:

Various types of material are produced by using nanotechnology techniques at nano scale level. Nanoparticle is wide class of nanotechnology having one dimension and particle size less than 100 nm. Nano particles has wide range of application in the field of biomedical because a large number of nano materials such as nano carriers, nanotubes, nanowires and nanorods have been developed. In this r... read more PDF     Full Text     Views (2372)

Oral Drug Delivery to the Experimental Animals, A Mini Review Arif Paiman, Ahmad Mohammadi, Rafia Inam, Aqsa Ameen, Mubashar Rehman Abstract:

In several pharmacologic, pharmacology, and alternative medicine studies, oral administration of medication or test substances to experimental animals is needed. It is clinically sound and recommended to administer test substances to experimental animals along the same route that they are taken or expected to be taken by humans as general bioavailability; the pharmacology and pharmacology param... read more PDF     Full Text     Views (2350)

Statistical Moment Theory and Non-Compartmental Analysis Samina Zehussain, Muhammad Ilyas, Abdullah , Mubashar Rehman, Abstract:

Mathematical model a numerical classification of the biological framework and utilized to state quantitative connections. A pharmacokinetic compartment is a numerical idea that portrays a space in the body that medication seems to possess These models just mediate the test information and permit an experimental equation for the assessment of medication focus with time. A non- compartmental mode... read more PDF     Full Text     Views (2303)


An Insight About the Drug Release Mechanisms from Different Dosage Forms Hafsa Shahid, Ayesha Ahmed, Ammarah Ashraf, Nida Rashid, Mubashir Rehman Abstract:

A process in which drug comes out from drug product and exposed to ADME and finally become accessible for pharmacological activity is known as drug release and mechanism involves the study of its rate and factors influencing its rate. Factors influencing the rate of drug release are drug related, polymer related and formulation variables. Drug delivery systems are discriminated on the basis of ... read more PDF     Full Text     Downloads (0)

Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing Duaa Aslam Chaudhry , Urooj Fatima , Kainat Waqar , Mubashar Rehman , Abstract:

Pharmacokinetic modeling helps to estimate the ADME parameters of all the natural and synthetic drug substances in humans and animals. There are two types of approaches for predicting the kinetic processes inside the body i.e., model approach and model independent approach. Model approach is further divided into compartmental and physiological models and model independent approach consists of n... read more PDF     Full Text     Downloads (0)

Oral Drug Delivery to the Experimental Animals, A Mini Review Arif Paiman, Ahmad Mohammadi, Rafia Inam, Aqsa Ameen, Mubashar Rehman Abstract:

In several pharmacologic, pharmacology, and alternative medicine studies, oral administration of medication or test substances to experimental animals is needed. It is clinically sound and recommended to administer test substances to experimental animals along the same route that they are taken or expected to be taken by humans as general bioavailability; the pharmacology and pharmacology param... read more PDF     Full Text     Downloads (0)

A Comprehensive Insight on Pharmacokinetics Urooj Naseem, Fatima Iqbal, Gul Shahnaz, , Abstract:

Pharmacokinetics can be defined as what the body does to a drug. The basic parameters of pharmacokinetics are discussed here including absorption, distribution, metabolism, and excretion. Characteristics and pathways taken by these drugs are determined by these parameters. The mechanism followed by these parameters are also discussed. Furthermore, the factors affecting these parameters includin... read more PDF     Full Text     Downloads (0)

Statistical Moment Theory and Non-Compartmental Analysis Samina Zehussain, Muhammad Ilyas, Abdullah , Mubashar Rehman, Abstract:

Mathematical model a numerical classification of the biological framework and utilized to state quantitative connections. A pharmacokinetic compartment is a numerical idea that portrays a space in the body that medication seems to possess These models just mediate the test information and permit an experimental equation for the assessment of medication focus with time. A non- compartmental mode... read more PDF     Full Text     Downloads (0)

Role of Computer Aided Drug Design in Modern Drug Discovery and Pharmacokinetic Prediction Arif Paiman, Ahmad Mohammad, Mubashar Rehman, , Abstract:

In modern day, Data on different diseases and drug substances with their properties like modification, side effects, and dose requires documentation data and building library exploring, such library with vast information in every aspect needs computational methods used in CADD. Recognition of specific targets for the drug tested and defining pharmacological activity of a drug candidate based on... read more PDF     Full Text     Downloads (0)

Role of Computer Aided Drug Design in Modern Drug Discovery and Pharmacokinetic Prediction Arif Paiman, Ahmad Mohammad, Mubashar Rehman, , Abstract:

In modern day, Data on different diseases and drug substances with their properties like modification, side effects, and dose requires documentation data and building library exploring, such library with vast information in every aspect needs computational methods used in CADD. Recognition of specific targets for the drug tested and defining pharmacological activity of a drug candidate based on... read more PDF     Full Text     Downloads (0)

A Review of Parenteral Administration of Testing Substance in Rabbit and Mice Muhammad Shehzeb Ashraf, Iqra Rehman, Gul Shahnaz, , Abstract:

There are many publications that deal with administration of test substances to animals and removal of blood samples for different objectives. Parenteral route of drug administration includes further different routes i.e., drug administration through muscles (IM route) through veins (IV route) and through subcutaneous route. We can manage to check the outcomes of test substances within minutes ... read more PDF     Full Text     Downloads (0)

A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs. Rabia Mazhar, Fariah Qaiser, Sana Ali Zahra, Syeda Komal Fatima, Imran Khan Abstract:

Oral route of drug administration is the most common among all routes and hence their pharmacokinetic and pharmacodynamic factors are substantial to study. Among such factors, GIT absorption is the key factor in new drug development affecting the efficacy as well as safety of the drug. Different protocols have now been developed for the usage of in vitro also the in vivo as well as in situ meth... read more PDF     Full Text     Downloads (0)

Strategies and Techniques of Drug Discovery from Natural Products Parniya Akbar Ali, Farah Hanif, Hosna Nettour, Mubashar Rehman, Abstract:

New drugs are mostly obtained from Natural sources. The traditional and ethic medicines have provided evidence on the therapeutic properties and resulted in some distinguished drug discovery of natural products. The microorganisms and the endogenous active materials from human or animal have also become a significant approach to the discovery of a drug. Bioinformatics and artificial intelligenc... read more PDF     Full Text     Downloads (0)